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KMID : 0356920070520050550
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Korean Journal of Anesthesiology
2007 Volume.52 No. 5 p.550 ~ p.555
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Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery
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Jung Jae-Sik
Jeon Young-Hun
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Abstract
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Background: Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery.
Methods: In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation.
Results: The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P ＜ 0.05). There were no significant differences between groups in adverse events.
Conclusions: Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects. (Korean J Anesthesiol 2007; 52: 550∼5)
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KEYWORD
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midazolam, middle ear surgery, postoperative nausea and vomiting (PONV)
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